Dr. Fleming is an Associate Professor in the School of Medicine, National University of Ireland, Galway, and Assistant Professor at the Leiden Academic Centre for Drug Research in Leiden University. Dr. Fleming leads the Systems Biochemistry Group, an interdisciplinary research group of mathematical, computational and experimental biologists. The fundamental interest is to develop scalable mathematical and numerical analysis techniques that increase the predictive fidelity of biomolecular network models, by incorporating physico-chemical constraints, motivated by optimality principles. Their applied interest is in the use of computational modelling to aid diagnosis, understand aetiopathogenesis and develop novel therapies for (i) heritable metabolic diseases, and (ii) neurodegenerative diseases, especially Parkinson’s disease. Computational model predictions are compared with quantitative clinical and experimental data, especially metabolomic data obtained from clinical biofluids and in vitro cell cultures.